​PEEK人工关节
​重构骨科植入物新生态

PEEK人工关节生物相容性体外细胞实验

1.Du Z, Wang S, Wang Y. Preferential CD8 rather than CD4 T-cell response to wear particles of polyether-ether-ketone and highly cross-linked polyethylene. RSC Adv., 2018, 8, 1866. 

2.Du Z, Wang S, Yue B, Wang Y, Wang Y. Effects of wear particles of polyether-ether-ketone and cobalt-chromium-molybdenum on CD4- and CD8-T-cell responses. Oncotarget. 2017 Dec 29;9(13):11197-11208. 

​

PEEK人工关节动物实验

1.Du Z, Zhu Z, Yue B, Li Z, Wang Y. Feasibility and Safety of a Cemented PEEK-on-PE Knee Replacement in a Goat Model: A Preliminary Study. Artif Organs. 2018 Aug;42(8):E204-E214. doi: 10.1111/aor.13101. Epub 2018 Feb 13. PMID: 29435992.

2.Meng X, Du Z and Wang Y. Characteristics of wear particles and wear behavior of retrieved PEEK-on-HXLPE total knee implants: a preliminary study. 30330. RSC Adv., 2018, 8, 30330–30339. 

​

PEEK全膝关节假体减少了应力屏蔽

1.Zhao G, Luo J, Ma J, Wang J. Decreased stress shielding with poly-ether-ether-ketone tibial implant for total knee arthroplasty - A preliminary study using finite element analysis. Heliyon. 2024 Feb 29;10(5):e27204. 

2.De Ruiter L, Janssen D, Briscoe A, Verdonschot N. A preclinical numerical assessment of a polyetheretherketone femoral component in total knee arthroplasty during gait. J Exp Orthop. 2017 Dec;4(1):3.

​

PEEK关节磨损性能评价

1.ZHANG X, ZHANG T, CHEN K, XU H, FENG C, ZHANG D. Wear mechanism and debris analysis of PEEK as an alternative to CoCrMo in the femoral component of total knee replacement. Friction 11(10): 1845–1861 (2023)

2.Cowie, R.M.; Pallem, N.M.; Briscoe, A.; Jennings, L.M. Third Body Wear of UHMWPE-on-PEEK-OPTIMA™. Materials 2020, 13, 1264

​

PEEK植入物-骨水泥界面

Zhao, G., Yao, S., Sun, X. Ma J., Wang J. Consequences of using poly-ether-ether-ketone versus traditional implant on tibial cement penetration and short-term clinical outcomes during total knee arthroplasty: a randomized controlled trial. J Orthop Surg Res 18, 589 (2023). 

​

磁共振成像、CT和X射线对PEEK人工关节体内评估  

Cai Z, Qu X, Zhao Y, Yuan Z, Zheng L, Long T, Yao Q, Yue B, Wang Y. Preliminary Study on Immediate Postoperative CT Images and Values of the Modular Polyetheretherketone Based Total Knee Arthroplasty: An Observational First-in-Human Trial. Front Surg. 2022 Feb 14;9:809699. doi: 10.3389/fsurg.2022.809699. 

​

髋关节、表面修复等其他部位研究

Meng X, Zhang W, Yuan Z, Chen J, Lyu Z, Wang Y. A partial hemi-resurfacing preliminary study of a novel magnetic resonance imaging compatible polyetheretherketone mini-prosthesis for focal osteochondral defects. J Orthop Translat. 2020 Mar 20;26:67-73. doi: 10.1016/j.jot.2020.02.010. 

​

 

表面改性：骨生成、抗菌、耐摩擦

1.Huo S, Meng X, Zhang S, Yue B, Zhao Y, Long T, Nie B, Wang Y, Hydrofluoric acid and nitric acid cotreatment forbiofunctionalization of polyetheretherketone in M2macrophage polarization and osteogenesis, J Biomed Mater Res.2021;109:879–892. 

2.Meng X., Zhang J., Chen J., Nie B., Yue B., Zhang W., Lyu Z., Long T., Wang Y., KR-12 coating of polyetheretherketone (PEEK) surface via polydopamine improves osteointegration and antibacterial activity in vivo. J. Mater. Chem. B, 2020,8, 10190-10204

3.Wu T, Zhang X, Chen K, Chen Q, Yu Z, Feng C, Qi J,Zhang D,The antibacterial and wear-resistant nano-ZnO/PEEK composites were constructed by a simple two-step method, Journal of the Mechanical Behavior of Biomedical Materials, Volume 126, February 2022, 104986

4.Feng C, Cao Y, Wu T, Cen J, Chen K, Li X, Zhang D, Friction and wear mechanism of artificial joint composite material PEEK/ZnO under different decomposition motion modes of knee joint, Tribology International, Volume 189, November 2023, 108917

5.Scholes SC, Unsworth A. The wear properties of CFR-PEEK-OPTIMA articulating against ceramic assessed on a multidirectional pin-on-plate machine. Proc Inst Mech Eng H. 2007 Apr;221(3):281-9. doi: 10.1243/09544119JEIM224.